Subgenual cingulate connectivity as a treatment predictor during low-frequency right dorsolateral prefrontal rTMS: A concurrent TMS-fMRI study
Subgenual cingulate connectivity as a treatment predictor during low-frequency right dorsolateral prefrontal rTMS: A concurrent TMS-fMRI study
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Introduction: Repetitive transcranial magnetic stimulation (rTMS) to iphone 14 price san francisco the dorsolateral prefrontal cortex (DLPFC) is effective in alleviating treatment-resistant depression (TRD).It has been proposed that regions within the left DLPFC that are anti-correlated with the right subgenual anterior cingulate cortex (sgACC) may represent optimal individualized target sites for high-frequency left rTMS (HFL).Objective/hypothesis: This study aimed to explore the effects of low-frequency right rTMS (LFR) on left sgACC connectivity during concurrent TMS-fMRI.
Methods: 34 TRD patients underwent an imaging session that included both a resting-state fMRI run (rs-fMRI0) and a run during which LFR was applied to the right DLPFC (TMS-fMRI).Participants subsequently completed four weeks of LFR treatment.The left sgACC functional connectivity was compared between the rs-fMRI0 run and TMS-fMRI run.
Personalized e-fields and a region-of-interest approach were used to calculate overlap of left sgACC functional connectivity at the TMS target and to assess for a relationship with treatment effects.Results: TMS-fMRI increased left sgACC functional connectivity to parietal regions within the ventral attention network; differences were not significantly associated with clinical improvements.Personalized e-fields were not significant in predicting treatment outcomes (p = 0.
18).Conclusion: This was the first study to examine left sgACC anti-correlation with the right DLPFC during an LFR rTMS protocol.In contrast to studies that targeted the left DLPFC, we collegiate graduate saddle did not find that higher anti-correlation was associated with clinical outcomes.
Our results suggest that the antidepressant mechanism of action of LFR to the right DLPFC may be different than for HFL.